Biochemistry · Structural Biology · Oncology
Aleksandra A. Zagulyaeva, PhD
Biochemist and protein scientist in Greater Boston
Bio
Research across chemistry, protein science, and structural biology
Science in service of better outcomes
Aleksandra A. Zagulyaeva—Sasha—is a biochemist and protein scientist whose experience spans small-molecule synthesis, biological engineering, and the structural characterization of protein complexes. She brings an adaptable, cross-disciplinary approach to complex research questions.
Her work is driven by collaborative discovery and a commitment to advancing oncology research toward meaningful benefits for patients. She values rigorous experimentation, continuous learning, and teams where ideas and expertise can move freely.
A Curriculum Vitae (CV) can be made available upon request. Reach out on LinkedIn.
Selected publications
Peer-reviewed work in oncology, protein science, structural biology, and organic chemistry
-
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
-
TRI-611, a selective, CNS-penetrant molecular glue degrader of ALK with anti-tumor activity against preclinical models of ALK-fusion positive non-small cell lung cancer including kinase inhibitor refractory tumors
-
TRI-611, a development stage molecular glue degrader of ALK for the treatment of ALK-positive NSCLC including central nervous system metastases
-
TRI-611, a development stage molecular glue degrader of ALK, promotes the degradation of TKI-resistant ALK fusion proteins and leads to regression of ALK TKI-refractory tumors
-
TRI-611, a potent, selective, CNS-penetrant ALK molecular glue degrader for the treatment of ALK-fusion protein positive non-small cell lung cancer
-
Structural Biology of Nonribosomal Peptide Synthetases
-
A General and Convenient Preparation of [Bis(trifluoroacetoxy)iodo]perfluoroalkanes and [Bis(trifluoroacetoxy)iodo]arenes by Oxidation of Organic Iodides Using Oxone and Trifluoroacetic Acid
-
Hofmann Rearrangement of Carboxamides Mediated by Hypervalent Iodine Species Generated in Situ from Iodobenzene and Oxone: Reaction Scope and Limitations
-
Iodine(V)/Ruthenium(III)-Cocatalyzed Oxidations: A Highly Efficient Tandem Catalytic System for the Oxidation of Alcohols and Hydrocarbons with Oxone
-
1,3-Dipolar Cycloaddition of Schiff Bases and Electron-Deficient Alkenes Catalyzed by α-Amino Acids
All models are wrong, but some are useful.
George Box
Being a professional means doing your job on the days you don't feel like doing it.
David Halberstam
The science of today is the technology of tomorrow.
Edward Teller
Contact
Connect to discuss research, scientific collaboration, and new opportunities
- Location
- Greater Boston, Massachusetts, USA
- aleksandrazagulyaeva